Endocrine Abstracts

Case: In April 2008, a 68-year-old male was referred to the endocrine clinic with symptoms of hyperthyroidism and was prescribed carbimazole 20 mg daily. A week later, he developed sudden onset dizziness, together with reduced hearing in his left ear and associated tinnitus. Similar symptoms developed in his right ear shortly thereafter. Seven weeks after starting carbimazole, he attended the ENT outpatient clinic with severe vertigo, tinnitus and bilateral hearing loss. Otosc...

Background: 20% of patients with acromegaly can have visual field defect due to compression of optic chiasm. This patient presented with visual field defect but no evidence of pressure effect on optic chiasm, but later found to have pituitary macroadenoma and acromegaly.Clinical Details: 59 yr old man presented 7 years ago to ophthalmologist with left inferior field defect of 2 months duration. The field defect was confirmed with perimetry. Subsequent CT...

IntroductionRenal disease in type 2 diabetes can be prevented and limited with early detection and management of the condition. We studied the adherence of renal guidelines introduced by national institute of clinical excellence (NICE), in patients who attended the annual review in the last 12 months.MethodsAudit standards were based on guidelines for Prevention and Early Management of Renal disease in Type 2...

Radioiodine therapy (RAI) is widely used as definitive treatment for hyperthyroidism. Of the several regimes in use, we have used a standard 555 MBq dose of RAI to treat all patients with hyperthyroidism. Treatment is considered to have failed if patients remain hyperthyroid at 12 months and a repeat 555 MBq dose is administered. We have studied 584 consecutive patients for failure rate of RAI when it is used according to this regime (mean follow-up 3 years (range 1-10)). We h...

Background: Preeclampsia (PE) continues tochallenge both the clinicians and researchers worldwide, as the existing knowledge on its etiopathology does not come up with an efficient and foolproof treatment regime due its progressive nature and uncertain diagnosis and prognosis. In this context, miRNAs represent a potential therapeutic target and a diagnostic tool.Objectives: Circulating microRNAs present in maternal blood play an important role in the eti...

AbstractThe diagnosis of osteomyelitis in diabetes mellitus remains a challenge. This study was conducted to evaluate the infection scintigraphy with instantly prepared single vial kit, radio-labelled ciprofloxacin (Diagnobact TM), as a mean to detect bone infection; in comparison with bacterial culture as gold standard. Written consent was taken from all patients including approval from institute ethics committee. Twenty-five patients with diabetic foot...

Introduction: Germline mutations in succinate dehydrogenase subunit B (SDHB) are one of the commonest findings in familial paraganglioma (PGL) syndromes and account for one quarter of PGLs associated with germline mutations. Although the penetrance is low, the malignancy conversion is high; up to 30%. With the increasing availability of genetic testing and the identification of ‘asymptomatic carriers’ of the SDHB gene mutation, it is therefore impor...